About

I am Nitesh Kumar Podh a Ph.D. research scholar and Prime minister's research fellow (PMRF) at Indian Institute of Technology , Hyderabad.

I have completed my B.Sc. with Hons. in Zoology from Rajendra Autonomous college, Sambalpur University, followed by M.Sc. in Zoology (Biochemistry and molecular biology) from Banaras Hindu University, Varanasi . I have qualified several National level exams like GATE-XL,GATE-BT 2021, CSIR JRF- DEC 2019. I have been offered a Ph.D. position at Laboratory of Chromosome Dynamics and Gene Regulation under the supervision of Dr. Gunjan Mehta.

My research mainly focuses on Single molecule tracking/ imaging of Mitotic Cancer target Polo like kinase(Plk-1).

Nitesh Kumar Podh

Overview of My Research

My research mainly focuses on Single molecule tracking/ imaging of Mitotic Cancer target Polo like kinase(Plk-1).

Plk1 control several aspects of eukaryotic cell division and DNA damage response. Remarkably, Plk1 is
overexpressed in several types of cancer, hence, it is considered as a potential target for cancer therapy. This project will unravel the single-molecule dynamics of Plk1, yet unexplored biophysical property
of Plk1 action in healthy and cancerous cells, providing new avenue for drug development by modulating
its dynamics. Mechanistic understanding about Plk1 action may help treating several genetic disorders,
aneuploidy and cancers.

Published Work

Years of Research

Podh NK, Paliwal S, Dey P, Das A, Morjaria S, Mehta GD*. In-vivo Single-Molecule Imaging in Yeast: Applications and Challenges. Journal of Molecular Biology 2021; 433(22):167250. https://www.sciencedirect.com/science/article/abs/pii/S0022283621004836?via%3Dihub
Podh NK#, Das A#, Dey P, Paliwal S, Mehta G*. Single-Molecule Tracking for studying protein dynamics and target-search mechanism in live cells of S. cerevisiae. STAR Protocols (Cell Press) 2022. https://www.sciencedirect.com/science/article/pii/S2666166722007808.
Podh NK#, Das A#, Dey P, Paliwal S, Mehta G*. Single-Molecule Tracking Dataset of Histone H3 (Hht1) in Saccharomyces cerevisiae. Data in Brief 2023. https://doi.org/10.1016/j.dib.2023.108925.